What happens if you take CBD and Zoloft (Sertraline)?

take cbd with zoloft

The Effects of CBD oil and Zoloft together

On the surface, CBD and Zoloft can be used for very similar needs.

Both are billed as medication to support panic attacks, depression, anxiety and even PTSD.

But what happens if you take CBD and Zoloft (Sertraline) together?

These drugs have different modes of action, and finding out if there will be any severe side effects prior to going ahead is definitely the smartest thing you can do.

So the good news is, you are in the right place.

To kick us off, we should differentiate between CBD and Zoloft.

What is CBD?

CBD is a famous chemical combination of Cannabis sativa plants. 

CBD is also known as Cannabidiol. This component is naturally produced and can be mixed with some products such as oils and other eatables.

CBD is a psychotropic medication that has a huge amount of proven benefits.

Some of these are maintaining calmness, relaxation, and a great sleeping format.

These are the common reasons people take CBD. 

CBD use also deals with different situations, for example, anxiety, mood swings, insomnia, obsessive-compulsive disorder, chronic pain, and other medicinal purposes. 

How CBD And THC Work

Over 60 different elements are found in the marijuana tree, called Cannabinoids, which react to the body’s endocannabinoids system. 

It enters your body cyp450 enzymes, which are the metabolizing enzymes of the cyp450 system that oxidize the CBD at first.

The endocannabinoid system will set all functions from mind and body. 

We can sort two cannabinoid receptors that these cannabinoids gripped to.

For example, when THC enters the body, it will affect your brain’s memory coordination, immune system, and concentration then you will feel high as it increases tricyclic antidepressants. 

But, when a small dose of CBD enters your body, it won’t get you high. It will affect other pain receptors and mental health, for example, pain, anxiety, stress, etc.

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What is Zoloft (sertraline)?

Sertraline is a remedy (antidepressant medication), which reacts with the chemicals in the brain that are unstable or disturbed because of panic, anxiety, motor coordination, or other uncontrollable symptoms. 

It belongs to selective serotonin reuptake inhibitors (SSRIs). Which deals with panic, anxiety, stress disorders.

The function of Zoloft (sertraline)

Zoloft plays an important role in treating;

  • panic
  • Stress
  • Panic attacks
  • Depression
  • Anxiety
  • Obsessive-compulsive disorders

Zoloft interaction helps to improve sleep and mood and makes a person feel great and relaxed. 

Mood disorders and depression is a mental disorder, because of deficient serotonin levels.

Due to minimal research and studies on CBD effectiveness, it's not easy to decide if CBD is ok to use as counter medications for Zoloft (sertraline).

Serotonin levels and other hormones help to decrease the levels and fix moods such as;

  • Serotonin syndrome
  • Suicidal thoughts
  • Depression
  • Social anxiety disorder
  • Balance energy levels
  • Anxiety

It helps to maintain metabolism in the brain for a long time. Which keeps the patients feeling good for a long time. 

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Is it safe to take Zoloft (sertraline) and CBD together?

Sometimes, cannabis use with Zoloft can cause issues since there are not enough studies on these topics, so it’s always wise to consult with a medical expert.

For example, suppose you have talked with a doctor and they provided you the leading prescription medications, then you started using CBD and Zoloft, and are feeling poorly from the CBD’s effects. 

If this is the case, you should stop using these products and immediately get medical assistance.

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Is CBD a feasible substitute for Zoloft (sertraline)?

Due to minimal research and studies on CBD effectiveness, it’s not easy to decide if CBD is ok to use as counter medications for Zoloft (sertraline). 

CBD can certainly be used to support some of the same physical and mental disorders as Sertraline, but substituting it all together is a slightly different question.

If you are taking medical cannabis or CBD for the first time instead of Zoloft and you get adverse reactions, immediately stop the process and talk to the doctor for professional medical advice.

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CBD and Zoloft interaction with Food And Drink?

Sertraline and Alcohol

Some people use alcohol with sertraline, which is not recommended.

Alcohol can increase the nervous system’s negative effects. You will feel dizzy and will not be able to concentrate. 


If you feel that, talk to medical professionals.

CBD And Food

Sometimes food may affect immersion and blood levels of Cannabidiol. 

Taking Cannabidiol at the same time every day will prevent an alteration in blood circulations. 

Grapefruit warning is something you may have heard of.

It means CBD and Grapefruit juice both inhibit the metabolic process similarly.

If a patient takes CBD with grapefruit juice they should reduce the quantity of CBD. 

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Difficulties with Zoloft (sertraline)

There are a few things to know before using Zoloft.

Zoloft can be more critical in disturbing drug metabolism and a few situations mentioned below.

Destruction of Kidney and Liver

It is difficult for kidney and liver patients (liver enzymes) to process and therefore remove sertraline from the body. 

Anyone on medications for kidney or liver, who is seeking other treatments options, should consult with their healthcare provider before looking to Zoloft.

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Zoloft And Labor

Sertraline can be dangerous for pregnant patients. It could affect your unborn child in many ways before or after the pregnancy.

Breastfeeding: Breastfeeding moms can have small doses of sertraline, but exact dose sizes should be taken under the clear direction of your medical consultant.

Distinct Lack of Studies and Research

There are many studies and researches about medical marijuana that prove that CBD is a great product still, there is a large gap of fewer studies and research. 

Yet Harvard medical school emphasizes the wider use of CBD and the many benefits of its use.

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Pros and Cons of CBD and Zoloft

Pros and cons are inherent to every product. 

CBD and Zoloft are no different when it comes to this and they have some similar side effects.

Pros of CBD

    • According to (WHO) CBD is safe and suitable for medical use
    • CBD oil helps control anxiety disorders
    • Fast to Improve sleeping your cycle
    • Helps with bipolar disorder
    • Helps in maintaining blood pressure
    • Marijuana use and CBD use help in chronic pain relief

Cons of CBD

    • Quality of CBD products varies, so be careful before buying one yourself and avoid potential interactions
    • High doses may cause stomach upset and have other negative side effects on the human body
    • 40% of CBD products contain THC so, do your research before buying one to avoid potential drug interactions
    • Sertraline hydrochloride when combined with CBD causes side effects
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Pros of Zoloft

    • Zoloft has fewer side effects as compared to drugs of the same purpose. 
    • Zoloft can support people who are suffering from a traumatic stress disorder and panic disorder.
    • You will feel relaxed and happy after taking Zoloft.
    • It helps elderly patients to deal with depressive disorder and other medical conditions.

Cons of zoloft

    • Zoloft can cause diarrhea and other stomach problems. 
    • It can cause a risk of adverse effects regarding testosterone. 
    • It can cause sleeping disorders. 
    • Zoloft can cause dry mouth, body sweating, and shaking.

Taking CBD and Zoloft - The Bottom Line

According to the research and database from different sources, it’s proved that CBD and Zoloft have mostly the same disadvantages, after possible interactions with different hormones and causes possible side effects such as dizziness, chronic pain, etc. 

If we use CBD and Zoloft together, we will increase the extremity of potential side effects.

You can be stressed, so use it carefully under prescription drugs and ask for professional help along with little research before using them together.